Biodiversity Research Seminar Series (BRS)

BRS Iulia Darolti: Remarkable diversity of sex chromosome differentiation and dosage compensation in poeciliids

December 8, 2021, 12:00 pm to 1:00 pm

2212 Main Mall

host: Mank Lab

Title: Remarkable diversity of sex chromosome differentiation and dosage compensation in poeciliids

Abstract: Sex chromosomes have repeatedly evolved across the tree of life. An important question in sex chromosome research is why do some sex chromosomes undergo extensive recombination suppression and degeneration while others remain largely undifferentiated. Using whole genome and transcriptome sequencing data across poeciliids, livebearing fish that include the guppies, I characterized the structure and conservation of sex chromosome systems within the clade. My work has uncovered an extreme heterogeneity across these species in the extent of sex chromosome differentiation and Y decay. I explored the causes and consequences of this remarkable interspecific variation in sex chromosome evolution. Analyzing allele segregation patterns from pedigree data, I found that incomplete recombination events prevent some Y chromosomes from decaying. In another system, profound Y degeneration has led to the evolution of complete dosage compensation, the first such case identified in fish, and faster rates of coding sequence evolution on the X chromosome. Taken together, this comparative work has provided novel insights into the mechanisms of sex chromosome evolution.

Topic: Biodiversity Research Seminar
Start Time: Dec 8, 2021 11:47 AM

Meeting Recording:
https://ubc.zoom.us/rec/share/jjUJhA-h2QS3zYpVEiQYKYXDNlmDjyCOPR_-MkwgO…

Access Passcode: This presentation is available to the BRC community at UBC, but not a wider audience. Please contact Katie for the passcode.
 

  • Biodiversity Research Seminar Series (BRS)

Biodiversity Research Centre

2212 Main Mall
Vancouver, BC Canada V6T 1Z4
E-mail biodiversity.centre@ubc.ca

Research Excellence Clusters at UBC Vancouver is a joint initiative of the Provost and Vice-President, Academic, UBC Vancouver and the Vice-President, Research and Innovation. Funding support for the clusters is provided by Academic Excellence Funds – UBC Vancouver.

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